Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes
Identifieur interne : 003B22 ( Main/Exploration ); précédent : 003B21; suivant : 003B23Striatal microinfusion of Tourette syndrome and PANDAS sera: Failure to induce behavioral changes
Auteurs : Christopher R. Loiselle [États-Unis] ; Olivia Lee [États-Unis] ; Timothy H. Moran [États-Unis] ; Harvey S. Singer [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2004-04.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Antibodies, Bacterial (immunology), Antigens, Bacterial (immunology), Autoimmune Diseases (blood), Autoimmune Diseases (immunology), Autoimmune Diseases (microbiology), Bacterial Outer Membrane Proteins (immunology), Basal Ganglia (immunology), Basal Ganglia (metabolism), Basal Ganglia (pathology), Carrier Proteins (immunology), Child, Culture Techniques, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Injections, Intramuscular, M5 protein, Male, Mental Disorders (blood), Mental Disorders (immunology), Mental Disorders (microbiology), Nervous system diseases, PANDAS, Putamen (immunology), Putamen (pathology), Rats, Rats, Inbred F344, Streptococcal Infections (blood), Streptococcal Infections (complications), Streptococcal Infections (immunology), Tourette Syndrome (blood), Tourette Syndrome (immunology), Tourette Syndrome (microbiology), Tourette syndrome, antineuronal antibodies, stereotypies, striatal microinfusion.
- MESH :
- chemical , immunology : Antibodies, Bacterial, Antigens, Bacterial, Bacterial Outer Membrane Proteins, Carrier Proteins.
- blood : Autoimmune Diseases, Mental Disorders, Streptococcal Infections, Tourette Syndrome.
- complications : Streptococcal Infections.
- immunology : Autoimmune Diseases, Basal Ganglia, Mental Disorders, Putamen, Streptococcal Infections, Tourette Syndrome.
- metabolism : Basal Ganglia.
- microbiology : Autoimmune Diseases, Mental Disorders, Tourette Syndrome.
- pathology : Basal Ganglia, Putamen.
- Animals, Child, Culture Techniques, Disease Models, Animal, Enzyme-Linked Immunosorbent Assay, Humans, Injections, Intramuscular, Male, Rats, Rats, Inbred F344.
Abstract
Rodent striatal microinfusions have been suggested as a model for assessing the behavioral effects induced by antineuronal antibodies. We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10522
Affiliations:
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Loiselle</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Lee, Olivia" sort="Lee, Olivia" uniqKey="Lee O" first="Olivia" last="Lee">Olivia Lee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Moran, Timothy H" sort="Moran, Timothy H" uniqKey="Moran T" first="Timothy H." last="Moran">Timothy H. 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Singer</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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We used this approach to evaluate the proposed autoimmune etiology for Tourette syndrome (TS) and pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS). Sera were assessed from patients with TS (n = 9) preselected based on the presence of elevated enzyme‐linked immunosorbent assay optical densities against putamen homogenate and sera from patients with PANDAS (n = 8), selected from a larger group assayed for antibodies against a putamen synaptosomal preparation. The effect of antibodies against the streptococcal M5 protein were also studied. A total of 44 Fischer rats received bilateral infusion of sera: 23 ventral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 8 control); 21 ventrolateral striatum (5 PANDAS, 5 TS, 5 anti‐M5 protein, and 6 controls). Cannulas were placed bilaterally and symmetrically by stereotactic techniques. After animals were allowed to recover for 1 week, sera were microinfused for 3 days. Animal behavior was then simultaneously quantified by daily observation and monitoring using automated activity boxes for 10 days after infusion. No significant alterations in stereotypic behavior or movement were observed between the PANDAS, TS, or anti‐M5 protein and control groups. Our findings are in contrast to previous reports, and suggest the need for further investigations to determine the validity of the model and of autoimmune‐mediated hypotheses for pediatric movement disorders. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Loiselle, Christopher R" sort="Loiselle, Christopher R" uniqKey="Loiselle C" first="Christopher R." last="Loiselle">Christopher R. Loiselle</name></region><name sortKey="Lee, Olivia" sort="Lee, Olivia" uniqKey="Lee O" first="Olivia" last="Lee">Olivia Lee</name><name sortKey="Moran, Timothy H" sort="Moran, Timothy H" uniqKey="Moran T" first="Timothy H." last="Moran">Timothy H. Moran</name><name sortKey="Singer, Harvey S" sort="Singer, Harvey S" uniqKey="Singer H" first="Harvey S." last="Singer">Harvey S. Singer</name><name sortKey="Singer, Harvey S" sort="Singer, Harvey S" uniqKey="Singer H" first="Harvey S." last="Singer">Harvey S. Singer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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